Maintenance Chemotherapy in Ovarian Cancer: A Trial-Sequential Analysis
نویسندگان
چکیده
In patients with epithelian ovarian cancer who have achieved remission after initial surgery and induction chemotherapy, the role of maintenance chemotherapy is controversial. We carried out a trial-sequential analysis that included 4 randomised controlled trials. The end-point was progression at 3 years while the boundary for non-inferiority was set at ±20% in risk ratio. The results of our trial-sequential analysis indicated the futility of maintenance chemotherapy, i.e. proof of no effectiveness. Consequently, no further trials of this type should be performed to assess the effectiveness of this intervention in this clinical condition.
منابع مشابه
Should studies of maintenance therapy be maintained in women with ovarian cancer?
less of geography, ovarian cancer is associated with the highest case-fatality ratio among the gynecologic cancers, reflecting early peritoneal dissemination with advanced-stage disease at diagnosis. Patients undergo cytoreductive surgery and chemotherapy, generally with carboplatin and paclitaxel, and frequently achieve clinical complete remission. Modest incremental improvements in median pro...
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